Friday, April 26, 2024

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Mayo Clinic Minute: Treating Urinary Tract Infections

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Why Your Uti Test May Be Negative Even When You Have Symptoms

How about a study that looked at bacterial DNA in the urine of women with UTI-like symptoms who also had a negative culture test?

To summarize, the researchers looked at urine samples of women without symptoms and a group with UTI-like symptoms. They performed two tests: a culture test and a DNA-sequencing test that allows identifying if there is any bacterial DNA in the urine.

According to the study, 90.5% of symptomatic women with a negative urine culture tested positive for Escherichia coli bacteria with molecular methods compared to about 5.3% of women without symptoms.

This allowed the researchers to conclude that culture tests might not be sufficiently accurate and if a patient complains of urinary tract infection symptoms, she might as well be treated for an acute UTI.

The findings are gaining traction among chronic UTI sufferers who feel that the study finally gives more credibility to their complaints.

However, argues Dr. Hawes the significance of finding bacterial DNA may be different than the significance of finding live growing bacteria. Does the DNA stay around after an infection? If so, for how long? How do you determine antibiotic sensitivity based on DNA findings rather than live growth?.

As Dr. Hawes concludes, We dont yet understand the clinical significance of this data. In other words, do not dismiss the results of your culture test because of this study.

Which Antibiotic Will Work Best

Your doctor will take a urine sample to confirm that you have a UTI. Then the lab will grow the germs in a dish for a couple of days to find out which type of bacteria you have. This is called a culture. Itâll tell your doctor what type of germs caused your infection. Theyâll likely prescribe one of the following antibiotics to treat it before the culture comes back:

Which medication and dose you get depends on whether your infection is complicated or uncomplicated.

âUncomplicatedâ means your urinary tract is normal. âComplicatedâ means you have a disease or problem with your urinary tract. You could have a narrowing of your ureters, which are the tubes that carry urine from your kidneys to your bladder, a narrowing in the urethra which transports urine from the bladder out of the body, or, you might have a blockage like a kidney stone or an enlarged prostate . It’s also possible you have a urinary fistula or a bladder diverticulum.

To treat a complicated infection, your doctor might prescribe a higher dose of antibiotics. If your UTI is severe or the infection is in your kidneys, you might need to be treated in a hospital or doctor’s office with high-dose antibiotics you get through an IV.

Your doctor will also consider these factors when choosing an antibiotic:

  • Are you over age 65?
  • Are you allergic to any antibiotics?
  • Have you had any side effects from antibiotics in the past?

Also Check: How To Prevent Uti While Taking Antibiotics

Antibiotics That Shouldn’t Be A First Choice For Uncomplicated Utis

Other antibiotics appear to be overused, and some physicians may misuse non-recommended antibiotics as first-line treatments. Ciprofloxacin is used in 35% of uncomplicated UTIs, while levofloxacin is used in 2%. These antibiotics can be important treatments in some cases of more complicated UTIs, but can have dangerous side effects.

The U.S. Food and Drug Administration warns that the use of these drugs should be restricted because of their potentially disabling side effects involving tendons, muscles, joints, nerves and the central nervous system. Additionally, in many parts of the country, bacteria commonly causing UTIs are becoming resistant to these antibiotics.

Q: When Will A Doctor Prescribe A Single Dose Antibiotic For Uti

Podcast #131: Antibiotics for a UTI

A: Single dose antibiotic treatment may be recommended if a woman has an uncomplicated UTI, a history of chronic UTIs, is sexually active, or has no other underlying conditions that might make this type of treatment ill-advised. Be aware, however, that as of this writing, not all doctors have warmed to or adopted the single dose antibiotic treatment idea.

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Recurrent Utis And Further Testing

If youre experiencing recurrent UTIs, your doctor may want to get a better look to rule out the possibility of an obstruction. Exams used in these instances include:

  • An abdominal ultrasound, which uses ultrasound waves to produce an image of your urinary tract
  • IVP, or an X-ray image of your urinary tract enhanced by dye
  • A CT scan, which takes precise, detailed pictures of your urinary tract
  • Cystoscopy, where your physician inserts a tiny camera via your urethra so he or she can examine the bladder and/or get a tissue sample

UTIs are considered recurrent if you experience three infections within a 12-month period or two within six months.

When You Need Themand When You Dont

Antibiotics are medicines that can kill bacteria. Doctors often use antibiotics to treat urinary tract infections . The main symptoms of UTIs are:

  • A burning feeling when you urinate.
  • A strong urge to urinate often.

However, many older people get UTI treatment even though they do not have these symptoms. This can do more harm than good. Heres why:

Antibiotics usually dont help when there are no UTI symptoms.

Older people often have some bacteria in their urine. This does not mean they have a UTI. But doctors may find the bacteria in a routine test and give antibiotics anyway.

The antibiotic does not help these patients.

  • It does not prevent UTIs.
  • It does not help bladder control.
  • It does not help memory problems or balance.

Most older people should not be tested or treated for a UTI unless they have UTI symptoms. And if you do have a UTI and get treated, you usually dont need another test to find out if you are cured. You should only get tested or treated if UTI symptoms come back.

Antibiotics have side effects.

Antibiotics can have side effects, such as fever, rash, diarrhea, nausea, vomiting, headache, tendon ruptures, and nerve damage.

Antibiotics can cause future problems.

Antibiotics can kill friendly germs in the body. This can lead to vaginal yeast infections. It can also lead to other infections, and severe diarrhea, hospitalization, and even death.

Antibiotics can be a waste of money.

When should older people take antibiotics for a UTI?

10/2013

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What Are Possible Complications Of A Urinary Tract Infection

Most UTIs cause no complications if they spontaneously resolve quickly or if treated early in the infection with appropriate medications. However, there are a number of complications that can occur if the UTI becomes chronic or rapidly advances.

  • Chronic infections may result in urinary strictures, abscesses, fistulas, kidney stones, and, rarely, kidney damage or bladder cancer.
  • The rapid advancement of UTIs can lead to dehydration, kidney failure, sepsis, and death.
  • Pregnant females with untreated UTIs may develop premature delivery and low birth weight for the infant and run the risk of rapid advancement of the infection.

When To See A Medical Provider

What are some common antibiotics used to treat UTIs?

If you think you are experiencing symptoms of a UTI, dont wait to see a doctor.Most likely youll need an antibiotic prescription to treat the infection.

Your doctor might ask you to provide a urine culture to help determine whether you are suffering from a UTI. If so, they can prescribe antibiotics to help you feel better in just a few days. Urine cultures can help doctors know which bacteria is in your urine

If you are suffering from recurrent urinary tract infections, consider contacting a urologist to assess your urinary tract.

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Q: What Happens If I Take Antibiotics Too Often

A: It is up to your doctor to determine what is too often. But certainly, if you are back at the doctors office every month for another UTI, then you have a chronic infection situation , and your treatment will need to be adjusted. That may include taking a slightly smaller dose of antibiotics but for a much longer period of time.

Antiseptic Drug As Good As Antibiotics For Preventing Recurrent Urinary Tract Infections

And may also help tackle antibiotic resistance, say researchers

The antiseptic drug methenamine hippurate is as good as antibiotics for preventing recurrent urinary tract infections in women, finds a trial published by The BMJ today.

Its use as an alternative to antibiotics may also help tackle the global burden of antibiotic resistance, say the researchers.

Over half of women have at least one urinary tract infection in their lifetime, and recurrence occurs in about a quarter of women who have one episode.

Current guidelines recommend daily low dose antibiotics as the standard preventive treatment for recurrent UTI. But such long term use of antibiotics has been linked to antibiotic resistance, so research into non-antibiotic alternatives is urgently needed.

Methenamine hippurate is a drug that sterilises urine, stopping the growth of certain bacteria. Previous studies have shown that it could be effective in preventing UTIs, but the evidence is inconclusive and further randomised trials are needed.

So a team of UK researchers, led by clinicians and scientists from Newcastle-upon-Tyne, set out to test if methenamine hippurate is an effective alternative to standard antibiotic treatment for preventing recurrent UTI in women.

Their findings are based on 240 women with recurrent urinary tract infections requiring prophylactic treatment. On average before trial entry these women experienced over six UTI episodes per year.

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Strengths And Limitations Of This Study

  • To the best of our knowledge, this is the first multicentre study to evaluate fosfomycin tromethamine in the treatment of lower urinary tract infections in China.

  • We used the same dosage regimen for the different types of UTI. The dosage may not be sufficient for the complicated lower UTI, but may exceed the required dose for acute uncomplicated cystitis. Further studies using different dosing regimens for the different types of infection are needed.

  • As we aimed to evaluate the clinical, microbiological and overall efficacy of fosfomycin tromethamine, the study design did not include a control group.

Treatments For A Urinary Tract Infection

Antibiotics Aren

The type of treatment you are prescribed and the length of time you need to take medicine depends on your health history and the type of bacteria found in your urine.

Medications

Doctors commonly prescribe antibiotics for urinary tract infections. Amoxicillin is a type of antibiotic medicine that stops the growth of bacteria in your urine.

Amoxicillin comes as a capsule, tablet, or liquid to be taken by mouth. The medicine is taken two or three times a day with or without food. If you have a UTI and are prescribed an antibiotic like amoxicillin, you should start feeling better within a few days. It is important to remember that even though your symptoms may start to subside within a few days, you should continue to take your medicine as prescribed by your doctor. The treatment length depends on your unique circumstances.

Home care

A healthy lifestyle that includes methods like regular bathing and good hygiene may help you control and prevent urinary tract infections. These techniques include:

  • Choosing NOT to use or feminine hygiene products containing perfumes
  • Avoiding bath oils

Read Also: How To Heal Strep Throat Without Antibiotics

First International Scientific Symposium On Urinary Tract Infection

During the symposium, Dr. George Zhanel of the University of Manitoba Faculty of Medicine discussed antibiotic resistance in relation to UTI. Dr. Andrea Novelli of the University Hospital Careggi gave an overview of antibiotics therapy. Professor Nicola Petrosillo of Lazzaro Spallanzani spoke about the stewardship of community and hospital-acquired infections.

Dr. Kurt Naber of the Technical University of Munich presented international UTI treatment guidelines. Dr. Ricardo Manalastas, Jr. of the University of the Philippines College of Medicine tackled UTI in relation to pregnancy and menopause. Dr. Edsel Salvana of the National Institutes of Health, UP Manila presented local UTI treatment guidelines.

Its Perfect For Women With Stubborn Utis

Women who suffer from recurrent UTIs know that theyre annoying, inconvenient, and really expensive. But even so, many are also hesitant to try one-dose antibiotics for fear that this option is less powerful than week-long treatments. If youre also doubtful about the effectiveness of this particular type of drug, heres a good news.

A study found that single-dose UTI antibiotics are just as or even more effective as other treatment options. Thus, with this science-based evidence, you need not worry about its efficacy anymore.

Also Check: Can A Pharmacist Prescribe Antibiotics For Strep Throat

How Should I Take Nitrofurantoin

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take nitrofurantoin with food.

Shake the oral suspension well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

You may mix your liquid dose with water, milk, or fruit juice to make it easier to swallow. Drink the entire mixture right away.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Nitrofurantoin will not treat a viral infection such as the common cold or flu.

Nitrofurantoin is usually given for up to 3 to 7 days.

If you use this medicine long-term, you may need frequent medical tests at your doctor’s office.

Nitrofurantoin can cause unusual results with certain lab tests for glucose in the urine. Tell any doctor who treats you that you are using nitrofurantoin.

Store at room temperature away from moisture, heat, and light.

Dont Stop Without Talking To Your Doc

#1 Best Remedy for a UTI (Urinary Tract Infection)

Some serious infections such as tuberculosis and those affecting the bones, heart valves, or bloodstream require long courses of medication. In certain circumstances, you can start to feel better, but still have an active infection that requires treatment, Hicks says.

If you are taking an antibiotic for a more garden-variety illness such as a sinus infection, urinary tract infection, or pneumonia, Hicks says its very reasonable to call your doctor and ask if you can discontinue the drug once you have been free of fever for 48 hours and are feeling significantly better.

Just dont hang on to leftover antibiotics. Discard unused medication by returning it to the pharmacy or a community take-back program. Or mix the medication with an unpalatable substance such as kitty litter or coffee grounds, seal it in a bag, and throw it out with the household trash. Read more about safe ways to dispose of antibiotics and other unwanted medicines.

Editors Note: These materials are made possible by a grant from the state Attorney General Consumer and Prescriber Education Grant Program, which is funded by the multi-state settlement of consumer-fraud claims regarding the marketing of the prescription drug Neurontin .

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How K Health Can Help

Did you know you can get affordable UTI treatment with the K Health app? Download K to check your symptoms using our AI-driven symptom checker and, if needed, text with a doctor in minutes. K Healths board-certified, U.S.-based doctors can provide a treatment plan and, if required, a prescription to resolve your symptoms as soon as possible.

The Status Of Phenazopyridine

In 1983, the FDA published a Drug Efficacy StudyImplementation notice with conditions for approval and marketingof all phenazopyridine products.7 These includedsulfameth-oxazole/phenazopyridine combinations ,similar combination products, and single-entity phenazopyridineproducts. The FDA presented newlyrequired statements for all phenazopyridine products intended to relievesymptoms associated with a UTI. One of the statements was critical indetermining the length of dosing: Treatment of a urinary tractinfection with phenazopyridine HCl or a combination drug productcontaining phenazopyridine HCl should not exceed 2 days because there isa lack of evidence that the combined administration of phenazopyridineHCl and an antibacterial provides greater benefit than administration ofthe anti-bacterial alone after 2 days.7

The FDA also required the following carcinogenicitystatement on all phenazopyridine labels: Long-term administration ofphenazopyridine hydrochloride has induced neoplasia in rats and mice . Although no association betweenphenazopyridine hydrochloride and human neoplasia has been reported,adequate epidemiological studies along these lines have not beenconducted.7

The best known phenazopyridine nonprescription product is Azo Standard.9Azo Standard contains 95 mg of phenazopyridine per tablet and AzoStandard Maximum Strength contains 97.5 mg of phenazopyridine.10 The dosage of both is 2 tablets 3 times daily with or after meals as needed.

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Q: How Is A Single Dose Antibiotic Taken

A: Fosfomycin comes in powder form. You typically mix it with a half-glass of water and drink it straight away. Whether you take it with or without food makes no difference. Whether you take standard antibiotics or single dose antibiotics you will likely feel better in a few days. The difference is that you will not need to remember to take antibiotics twice a day for 10 days. This increases compliance and reduces the chance of recurrence.

Uti Symptoms Think Quick Grab A Urinary Pain Reliever

19X16: NICE update

When you suddenly feel the typical symptoms of a UTI, grab an over-the-counter urinary pain reliever with Phenazopyridine Hydrochloride to help relieve those symptoms fast. Then immediately head to the doctor to determine if it actually is a UTI. For many, UTI symptoms include urinating often, burning and strong odor in your pee, blood in the urine and soreness or a feeling of fullness in the bladder or lower back.2 Sounds awful, right? Dont even THINK about treating a possible urinary tract infection without the help of a medical professional. The bacteria that cause urinary tract infections can multiply at a frightening rate so make moves fast!

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