Chronic Urinary Tract Infection
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What is a chronic urinary tract infection?
Chronic urinary tract infections are infections of the urinary tract that either dont respond to treatment or keep recurring. They may either continue to affect your urinary tract despite getting the right treatment, or they may recur after treatment.
Your urinary tract is the pathway that makes up your urinary system. It includes the following:
- Your kidneys filter your blood and generate body waste in the form of urine.
- Your ureters are tubes that carry urine from the kidneys to the bladder.
- Your bladder collects and stores urine.
- Your urethra is the tube that carries urine from the bladder to the outside of your body.
A UTI can affect any part of your urinary system. When an infection only affects your bladder, its usually a minor illness that can be easily treated. However, if it spreads to your kidneys, you may suffer from serious health consequences, and may even need to be hospitalized.
Although UTIs can happen to anyone at any age, theyre more prevalent in women. In fact, the
The Best Antibiotics For Uti
The top antibiotics for UTI are:
- Trimethoprim/sulfamethoxazole This is a combination antibiotic drug used for treating UTI and other infections. The antibiotic works by preventing the growth of bacteria. It is available in tablet and suspension form and must be prescribed by a doctor. Side effects may include nausea, vomiting, and loss of appetite.
- Fosfomycin Fosfomycin is an antibacterial drug used for treating urinary tract infections. It kills bacteria that cause UTI. Fosfomycin is available by prescription only in tablet form. Fosfomycin side effects may include diarrhea, nausea, and headaches.
- Nitrofurantoin This antibiotic is frequently used to treat acute UTIs. Nitrofurantoin inhibits bacterial DNA, RNA, and protein synthesis. The most common side effects of Nitrofurantoin are nausea, loss of appetite, and vomiting.
- Cephalexin Cephalexin can treat a variety of bacterial infections, including UTIs. By inhibiting the formation of the bacterial cell wall, Cephalexin helps prevent the growth of bacteria causing a UTI. Cephalexin is available in capsule, and suspension form.
- Ceftriaxone Ceftriaxone injection also treats many different types of infections caused by bacteria. The injection may be administered in a doctors office or hospital. Ceftriaxone kills bacteria that cause urinary tract infections and is only available with a doctors prescription.
Option #: Bacterial Antibiotic Resistance
Have you taken all prescribed antibiotics but your symptoms are only getting worse? It could be that your bacteria are resistant to this type of drug.
You might have heard about superbug bacteria that withstand all available antibiotics. Well, increasingly, bacterial resistance is a real-life problem that physicians facing more often than before.
Here are the main signs that could signal that your bacteria are resistant to the prescribed medication:
- You are feeling worse, while youve been taking antibiotics diligently for over 48 hours.
- You are experiencing fever or nausea .
Realistically, you should feel much better by the third day of an antibiotic treatment, the bacterial load should be lowered, and therefore symptoms should subside, says Dr. Lisa Hawes even if not all symptoms resolved, you definitely should not have cloudiness, odor, or blood in your urine 48 hours after starting antibiotics.
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What Other Drugs Could Interact With This Medication
There may be an interaction between fosfomycin and any of the following:
- sodium picosulfate
- typhoid vaccine
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter , and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Monurol
How To Store And Dispose Of This Medicine:
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
- Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
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How Are Most Utis Diagnosed
There are several ways that your physician can diagnose a UTI. To provide the best antibiotic treatment for UTI, he or she needs to determine the location of the infection and whether your UTI is complicated. He or she also needs to rule out other conditions that present similarly to UTI, such as vaginitis or certain sexually transmitted diseases.
Most UTIs are diagnosed via urine test. In some instances, your healthcare provider may also order blood cultures and a complete blood count. These test results will confirm the type of bacteria, virus or fungus thats causing the infection.
Bacteria is to blame for the vast majority of UTIs, and theyre treated using a wide range of antibiotics. In rarer cases, where a virus is behind the infection, antivirals such as cidofovir are prescribed. Fungal UTIs are treated with antifungals.
What Conditions Can It Treat
Fosfomycin is FDA-approved to treat uncomplicated UTIs. Lets break this down.
Your urinary system is composed of your urethra, bladder, and kidneys.
Any of these areas can be affected by bacterial pathogens like E. coli, enterobacteriaceae such as enterobacter, enterococcus faecalis and other enterococci, staphylococcus aureus, or klebsiella pneumoniae.
A lower tract UTI, also known as a bladder infection, is the most common and easiest type of UTI to treat.
Symptoms include a burning sensation when you urinate, a frequent need to urinate, blood in the urine, and abdominal pain.
An upper tract UTI tends to occur as the result of an untreated lower tract UTI that spreads upward to the kidneys. This is called a kidney infection and can be serious, potentially requiring a hospital visit to avoid permanent organ damage.
Signs you might have a kidney infection include fever, lower back or side pain, chills, and nausea.
Uncomplicated UTIs are ones in which the persons urinary tract is normal and they have no history of health problems.
On the other hand, complicated UTIs occur when someone has a condition or anatomical abnormality blocking the urinary tract.
In addition to being used to treat uncomplicated UTIs, fosfomycin is currently being studied in the US for its potential ability to treat multidrug-resistant infections.
Its not approved for this use in the US, but in Europe, it is prescribed in intravenous form for this purpose.
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Warnings While Using This Medicine:
- Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease or diarrhea.
- This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop taking this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.
Generic Name: Fosfomycin Tromethamine
BRAND NAME: Monurol
USES: This medication is an antibiotic used to treat bladder infections in women. It works by stopping the growth of bacteria.Fosfomycin should not be used to treat infections outside the bladder .This antibiotic treats only bacterial infections. It will not work for viral infections . Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.
HOW TO USE: Use 1 packet only. This is a single-dose treatment. Always mix this drug with water. Pour the contents of 1 packet into at least a half glass of cold water and stir. Do not use warm or hot water. Drink the mixture immediately. This drug may be taken with or without food.Symptoms should improve within 2 to 3 days after taking this drug. If symptoms persist or worsen, contact your doctor promptly.
OVERDOSE: If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: hearing loss, metallic taste.
MISSED DOSE: Not applicable.
Information last revised March 2013. Copyright 2013 First Databank, Inc.
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What Are Alternative Solutions To Taking Antibiotics After Sex
As antibiotic resistance is on the rise, this form of treatment will become obsolete. Scientists still agree that prevention is the best treatment.
Any UTI prevention strategy should include common behavioral changes. Ask your doctor about what else you can do to avoid taking prophylactic antibiotics for your chronic UTIs.
Any UTI prevention strategy should include common behavioral changes. Ask your doctor about what else you can do to avoid taking prophylactic antibiotics for your chronic UTIs.
Can You Get Fosfomycin Online
You need a doctors prescription to get this antibiotic, but you dont necessarily need to see a doctor in person. K Health offers affordable outpatient treatment for all kinds of medical conditions, including UTIs, directly through your phone.
Chat with a doctor instantly to discuss your symptoms and whether an antibiotic like fosfomycin, nitrofurantoin, or carbapenem might be right for you. If so, you can get a prescription and either pick up the medication at your local pharmacy or have it delivered.
Our physicians can prescribe antibiotics for various conditions, but only if necessary. Chat with a provider to see which treatment option is best for you.
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Common Questions About Trimethoprim
Trimethoprim kills bacteria by stopping them making a substance called folic acid, which they need to survive.
This is why trimethoprim can sometimes cause low folic acid levels in your blood over time.
You should feel better within a few days.
It’s important that you keep taking trimethoprim until your course is finished.
Do this even if you feel better. It will help stop the infection coming back.
Tell your doctor if you do not start feeling better after taking trimethoprim for 3 days, or if you start to feel worse at any time.
Some people get a fungal infection called thrush after taking a course of antibiotics like trimethoprim.
It happens because antibiotics kill the normal harmless bacteria that help to protect you against thrush.
Ask your pharmacist or doctor for advice if this happens to you.
Yes. Trimethoprim should not affect you being able to drive or cycle.
There’s no evidence to suggest that taking trimethoprim reduces fertility in either men or women.
But if you’re trying to get pregnant and you are taking trimethoprim every day, talk to your doctor, as this medicine is not usually recommended in early pregnancy. They may recommend changing to another antibiotic, or they may also prescribe high dose folic acid .
Option #: Persistent Uti Symptoms After Treatment
Here is another option: they sent your urine sample to a lab and later told you that according to the test you have a UTI. However, antibiotics resolved some symptoms , but the urge to urinate or pain in the lower abdomen remained.
As you could imagine, there could be a scenario when not only you have a full-blown UTI, but also an inflamed bladder lining is causing additional symptoms, as discussed above.
In this case, you, most likely, will see a reduction in pain, and your urine will become clear. However, pain in the bladder area and slight irritation after urination might still linger.
Moreover, when patients mention they feel burning in the urethra rather than the bladder, its quite normal. In fact, the urethra has more nerve endings that could be easily irritated due to underlying inflammation.
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How To Use This Medicine:
- Your doctor will tell you how much medicine to use. Do not use more than directed.
- Only one dose of this medicine is needed to treat your UTI. The medicine stays in your body to fight the infection.
- You may take this medicine with or without food.
- The medicine is an orange-flavored powder that must be mixed with water before using. Never swallow the medicine in its dry form.
- Open the packet and pour all of the powder into 3 to 4 ounces of water. Do not use hot water.
- Stir until the powder is dissolved, and drink the mixture right away.
If a dose is missed:
- You should only use one dose of the medicine to treat your UTI.
Pharmacokinetics Route Of Administration And Dosage
Fosfomycin tromethamine, a synthetically prepared soluble salt with improved bioavailability, is the most commonly used oral form. Oral fosfomycin calcium is available in some countries, but appears to have decreased intestinal absorption. The intravenous formulation, available in some European countries, is fosfomycin disodium. Fosfomycin tromethamine has 3441% bioavailability, a mean elimination half-life of roughly 5.7 hours, negligible protein binding and is primarily excreted unchanged in the urine. It distributes well into the tissues, achieving clinically relevant concentrations in serum, soft tissues, lung, bone, cerebrospinal fluid, heart valves and the prostate.24,25 Fosfomycin crosses the placental barrier but appears safe for use in pregnancy no teratogenicity in animals or adverse fetal effects in humans have been observed.14
Fosfomycin tromethamine is given as a single oral dose of 3g for UTIs. The drug is not recommended in children weighing less than 50kg. Intake with food leads to decreased serum concentrations, as does co-administration with metoclopramide. Intravenous fosfomycin disodium is given as a total daily dose of 100200mg/kg it is typically administered every 812 hours in extended infusions of 4g lasting 48 hours.
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Preindex Date Antibiotic Use And Urine Cultures
Preindex date antibiotic use occurred in 140 episodes , with a meanâÂ±âSD of 2.3âÂ±â1.4 antibiotic courses administered in each episode before MDF . The most common antibiotics prescribed pre-MDF included oral cefuroxime , ciprofloxacin , and nitrofurantoin .
Most episodes had a urinary culture within 90 days before the index date , and 112 episodes had both pre- and posttreatment urinary cultures. Seven of the 167 pretreatment cultures were polymicrobial . Fourteen cultures grew normal flora or had insufficient growth and were excluded from the antibiotic susceptibility descriptions. From 167 pretreatment cultures, 165 organisms with reported susceptibilities were isolated . The most common organism isolated was E coli other species occurred withâ< 10% frequency each. Organisms generally demonstrated a high degree of antibiotic nonsusceptibility. Fosfomycin susceptibility was available for 69 organisms the majority were susceptible . One isolate of E coli was intermediately susceptible to fosfomycin, and 1 additional E coli isolate was resistant.
Does Taking An Antibiotic After Sex Prevent Utis
According to the American Academy of Family Physicians, having sex three or more times a week increases your risk for recurrent UTIs. Your risk is also increased if you use a diaphragm or spermicide products, regardless of the frequency of sexual activity. If you experience recurrent UTIs,changing your method of contraception should be the first thing you consider.
If you continue to suffer from UTIs and they are getting in the way of living a normal life, taking a preventive antibiotic could be an option. Taking regular antibiotics is not a risk-free treatment though, so have a conversation with your provider about whether this is right for you. Taking an antibiotic before or after sex can prevent recurrent UTIs especially if UTIs repeatedly show up 24 hours after intercourse.
During sex, bacteria can get into the urinary tract and cause infections. Antibiotics work by fighting these bacteria. E. coli is the most common bacteria that causes UTIs. Common antibiotics used to treat UTIs are nitrofurantoin, cephalexin, or trimethoprim/sulfamethoxazole .
A clinical trial showed that only 2 out of 16 women who took TMP/SMX right after sex had recurrent UTIs compared to 9 out of 11 women who had a sugar pill. The results were the same regardless of how often the women had sex.
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Single Dose Monurol For Treatment Of Acute Cystitis
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|Verified November 2017 by Ann Stapleton, University of Washington. Recruitment status was: Active, not recruitingFirst Posted : September 15, 2009Last Update Posted : November 17, 2017|
Urinary tract infecton is a very common problem in young healthy women, afflicting approximately one-half of women by their late 20âs. One of the most common antibiotics used to treat UTIs is Trimethoprim-sulfa , usually for total of three days. However, concerns about increased antibiotic resistance have led to increased interest in studying other antibiotics for UTI.
An alternative antibiotic which is also FDA approved for the treatment of UTIs is fosfomycin . The effectiveness of fosfomycin in curing UTIs when given as a single dose is not well studied. The purpose of this research study is to determine what the cure rates are with a single dose of fosfomycin versus the more standard 3-day course of TMP-SMX.Condition or disease
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