Monday, December 5, 2022

How To Combat Antibiotic Resistance

In The Last Couple Of Decades Weve Seen Decreases In Prescription To Children In The Us Dr Katherine Fleming

How to prevent antibiotic resistance

Then, last year, the UN addressed the issue before the General Assembly only the fourth time in history that a health issue was discussed there. And just this May the G20 leaders signed a declaration on global health that included tackling antibiotic resistance. So its definitely a grand challenge that world leaders are taking seriously.

Worldwide consumption of antibiotics has skyrocketed in recent years: One study found that global consumption went up 30% between 2000 and 2010.

Much of the WHO action plan focuses on hospital stewardship and supervision. The CDC is currently working closely with American hospitals to provide guidelines and education for the safe and reasonable prescription of antibiotics. We have made some progress, says Dr Katherine Fleming-Dutra, an epidemiologist at the CDC. In the last couple of decades weve seen decreases in prescription to children in the US. We have seen less progress in adults. The rate in adults has been relatively stable.

Once hospitals and physicians get on board with reducing prescriptions the next step is to change regulations around agriculture.

But other countries need to follow suit as evidenced by the recent revelations about antibiotic resistance coming out of China.

Viruses That Prey On Bacteria

One possible solution is for healthcare professionals to enlist the help of bacteriophages, or phages, which invade bacteria and hijack their cellular machinery to make copies of themselves. In the process, this kills the bacteria.

Bacteriophages are the most abundant biological entities on the planet. By keeping bacteria in check, they help maintain a healthy balance between microorganisms.

The French microbiologist Félix dHérelle discovered bacteriophages more than 100 years ago and came up with the idea that they could treat bacterial infections. In 1919 , he used a cocktail of phages to cure four patients of dysentery.

With the development of highly effective antibiotic drugs in the following decades, phage therapy fell out of favor. But there has been a revival of interest in recent years as a possible way to address the growing threat of antibiotic resistance.

One of the challenges for researchers has been to recreate how phages and their bacterial hosts behave in the human body in the laboratory.

When scientists grow bacteria and phages together in a flask, the bacteria evolve rapid genetic resistance to the viruses.

However, a new study has found that in an environment that more closely resembles the nooks and crannies of the human body, such as blood capillaries or the alveoli or air sacs in the lungs, bacteria do not develop genetic resistance to phages.

The scientists recently published their research in PLOS Biology.

Understanding And Treating Drug

Professor Upton and his team study pathogens that cause drug resistant infections. A particular focus is on urinary tract infections which are one of the most common bacterial infections and the cause of enormous levels of antibiotic prescription, much of which is not necessary or justified.

Professor Upton said:

We have significant expertise in analysis of the genetic relationships of these bacteria , which helps us understand the factors that lead to development of antibiotic resistance and the way the infections are spread.We use the Galleria mellonella larvae infection model, cell culture and high-resolution proteomic methods to analyse the pathogenicity of these bacteria. By understanding the way that these bacteria cause disease and avoid the action of our immune system, we aim to identify new targets for therapeutic drugs and vaccines.

Find out more about the work of PIHR

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Surveillance Of Antibiotic Resistance And Antibiotic Use

All over the world, surveillance is considered as strength of the programmes directed towards AMR. The objective of surveillance is to facilitate the containment of antibiotic resistance. It is a useful tool that generates data on antimicrobial use and AMR which is essential in updating national EDLs and formulating infection control policies. It may also help in improving antimicrobial prescribing and development of empirical therapy or standards treatment guidelines .National policy on AMR in India recommend three types of surveillances which include comprehensive surveillance, sentinel surveillance, and point prevalence .

Can You Prevent Antibiotic Resistance

Health Observation: Antibiotic Resistance at A Glance

These steps may lower your risk of developing antibiotic resistance:

  • Only take antibiotics prescribed for you. Dont take someone elses medicine.
  • Follow your healthcare providers advice to treat your symptoms without antibiotics. Dont pressure your provider for an unnecessary prescription.
  • Set a reminder on your phone so you dont miss a dose. If you do forget to take your medicine, ask your provider what to do.
  • Take all of the medicine as prescribed, even if you feel better. If you stop an antibiotic too soon, bacteria can start to grow again, and they may develop resistance.
  • Wash your hands regularly. Good hygiene lowers your risk of getting a bacterial infection.

A note from Cleveland Clinic

Bacteria that develop antibiotic resistance dont respond to standard treatments. The result can be a bacterial infection thats difficult to treat. Antibiotic resistance is a worldwide health problem. To help prevent drug resistance, healthcare providers prescribe antibiotics only when needed. Overuse and misuse of antibiotics are top contributors to antibiotic resistance. Be sure to follow your providers instructions. Take antibiotics only when necessary and exactly as prescribed.

Last reviewed by a Cleveland Clinic medical professional on 06/23/2021.

References

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The Global Antimicrobial Resistance And Use Surveillance System

WHO launched the Global Antimicrobial Resistance and Use Surveillance System in 2015 to continue filling knowledge gaps and to inform strategies at all levels. GLASS has been conceived to progressively incorporate data from surveillance of AMR in humans, surveillance of the use of antimicrobial medicines, AMR in the food chain and in the environment. GLASS provides a standardized approach to the collection, analysis, interpretation and sharing of data by countries, territories and areas, and monitors the status of existing and new national surveillance systems, with emphasis on representativeness and quality of data collection. Some WHO regions have established surveillance networks that provide technical support to countries and facilitate enrollment into GLASS.

Just Scratching The Surface

All of this evidence indicates that antibiotic treatment selects for genes conferring antibiotic resistance, that these increases in resistance can persist for many years, and that these resistance genes can be exchanged within the commensal microbiota as well as with foreign microbes. As with the soil, we and others in our field have also begun to appreciate that this portrait of the human commensal resistome is a vast underestimate due to an over-reliance on culture-based methods.

An FDA microbiologist holds tomatoes being tested for salmonella . Genetic sequences of all bacteria and allcultured bacteria from two healthy individuals are compared with sequences cataloged by the National Centerfor Biotechnology Information . The cultured resistome overlaps greatly with the NCBI sequences and with resistance genesin common pathogens.

Adapted by Barbara Aulicino from M. O. A. Sommer et al., Virulence 2010 1:299

The most resounding message that comes through from every new resistome study is that the pool of resistance genes, and the mechanisms of resisting antibiotics, available to bacteria are effectively limitless.

References

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Strategies To Combat Antibiotic Resistance In Healthcare

The global nature of antibiotic resistance calls for a global response, both in the geographic sense and across the whole range of sectors involved. In line with a One Health approach, healthcare plays a central role in preventing the emergence and spread of antibiotic resistance.We all have to participate in this challenge!

  • to improve awareness and understanding of antimicrobial resistance
  • to strengthen knowledge through surveillance and research
  • to reduce the incidence of infection
  • to optimize the use of antimicrobial agents and
  • to develop the economic case for sustainable investment that takes account of the needs of all countries, and increase investment in new medicines, diagnostic tools, vaccines and other interventions.

The global nature of antibiotic resistance calls for a global response, both in the geographic sense and across the whole range of sectors involved. In line with a One Health approach, healthcare plays a central role in preventing the emergence and spread of antimicrobial resistance.We all have to participate in this challenge!

Promotion of awareness of all the stakeholders

Containment of bacterial transmission and prevention of infection

  • cut off any route of transmission.

Surveillance of healthcare-associated infections and antibiotic resistance

Antibiotic stewardship

Education for changing behavior

Plymouth Institute Of Health And Care Research

How do we combat antibiotic resistance?| Dag Berild | TEDxArendal

The Plymouth Institute of Health and Care Research is a thriving community that conducts adventurous world-leading research with the explicit purpose of improving the health and care of the populations we serve.

Our work is grounded in the needs of the people of the South West and other rural, coastal, and deprived communities worldwide, but PIHRs research has national and international reach and impact.

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Study Biomedical Sciences At Plymouth

Our three core aims: outstanding clinical education strong social engagement and world-class research feature strongly in your learning experience when you come to study biomedical sciences with us.

A key strength is our close relationship with NHS partners, with early clinical contact for all our students. Our biomedical sciences students have access to some of the best-resourced laboratories in the UK, pursuing research grounded in the real world of clinical health care.

We are looking for highly motivated and talented students to join us and become the next generation of biomedicine research scientists.

Don’t Use Antibiotics Left Over From A Previous Prescription

The type, dose and amount of antibiotics left over may not be enough to fight a new infection. This creates more opportunity for resistant bacteria to develop and multiply. Different infections may need different treatments, even though you might have similar symptoms. If your condition is caused by bacteria, to treat it effectively you need to get the right antibiotic, at the right dose, for the right period of time. Using antibiotics when they are not needed or taking the wrong antibiotic exposes bacteria to antibiotics unnecessarily, which encourages antibiotic resistance.Another thing to keep in mind is that just like food, antibiotics go off. Keeping leftover antibiotics may lead you to take expired medicines, which means they may not work when you need them or may make you feel more ill. Liquid antibiotics often need to be kept in the fridge and expire quickly other antibiotics may not be labelled with a specific expiry date.

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What Main Issue Are You Exploring

Arshad: Our work focuses on understanding antimicrobial resistance in different healthcare systems across the world. We are trying to better understand how these highly resistant bacteria spread across different communities and patient populations, and also understand what we can do to better treat and control their spread.

Hartmann: The problem that we are facing is that our arsenal of antibiotics is not expanding, and at the same time, pathogens are developing resistance to existing antibiotics. This means that diseases that we used to be able to treat very easily are becoming much more difficult to manage and even fatal. In 2019 alone, there were an estimated 5 million deaths attributed to some form of antimicrobial resistance worldwide, and that number is only expected to increase.

Should You Finish A Course Of Antibiotics

WHO: World Antibiotic Awareness Week 2017

Often you will feel better before your course of antibiotics is finished. More studies are showing that shorter courses of antibiotics are just as effective as longer courses. However, treatment guidelines are being updated with this new information, so your prescriber will take this into account when they decide your treatment. For some infections it is important to take antibiotics for a while after you feel better to make sure the infection is gone, so it is always best to complete your antibiotics as advised the prescriber. If in doubt, talk to your prescriber.

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What Are Bacteria And Viruses

Bacteria are single-celled organisms usually found all over the inside and outside of our bodies, except in the blood and spinal fluid. Many bacteria are not harmful. In fact, some are actually beneficial. However, disease-causing bacteria trigger illnesses, such as strep throat and some ear infections. Viruses are even smaller than bacteria. A virus cannot survive outside the bodys cells. It causes illnesses by invading healthy cells and reproducing.

New Treatment For Antibiotic Resistant Bacteria And Infectious Disease

Date:
University of Birmingham
Summary:
A new treatment pathway for antibiotic resistant bacteria and infectious diseases with benefits for patients and health care providers has been described in a new report.

A study, published in the American Journal of Respiratory and Critical Care Medicine, describes a new treatment pathway for antibiotic resistant bacteria and infectious diseases with benefits for patients and health care providers.

Researchers from the University of Birmingham and Newcastle University found that the unusual approach of removing antibodies from the blood stream reduced the effects of chronic infections, the requirement for days spent in hospital and the use of antibiotics.

In this study, the team identified two patients with bronchiectasis who suffered with chronic Pseudomonas aeruginosa infections that were resistant to many antibiotics a 64-year-old male, diagnosed with bronchiectasis aged fifteen, and a 69-year-old female who had bronchiectasis from childhood.

Bronchiectasis is a disease that leads to permanent enlargement of the airways in the lung and affects over 300,000 patients in the UK. Symptoms are debilitating for patients, and typically include a chronic cough, shortness of breath, coughing up blood, and chest pain. Bronchiectasis often affects patients beyond the age at which lung transplantation is possible.

The patients volunteered to be part of an explorative treatment that built on previous findings from the research group in 2014.

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How Pathogens Fight Back

Just as there are a number of different ways for bacteria to acquire an antibiotic resistance gene, the genes themselves represent a number of different strategies to encode resistance. The genes that confer antibiotic resistance can be loosely separated into four groups, each with their own unique mechanism for combating antibiotic exposure.

Four mechanisms of resistance: impermeable barrier blocks antibiotics because the bacterial cell membrane is nowimpermeable to the drug. Target modification alters the proteins inhibited by the antibiotic, so the drug cannot bind properly.Antibiotic modification produces an enzyme that inactivates the antibiotic. Efflux employs genes coding for enzymes that actively pump the antibiotic out of the cell.

Illustration by Barbara Aulicino

In antibiotic modification, a resistance gene can encode an enzyme that helps break down or modify the antibiotic before it can kill the bacteria. This tactic is often used against beta-lactams, the most widely prescribed and diverse chemical class of antibiotics, which includes the well-known drug penicillin. Penicillin inhibits enzymes that remodel the bacterial cell wall and are essential for the cell during growth. Resistance toward penicillin is frequently conferred by beta-lactamases, enzymes that cleave the penicillin molecule to render it ineffective in inhibiting the cell wall modification enzymes.

Never Share Antibiotics With Others

What can I do to help prevent antibiotic resistance? | Apollo Hospitals

Antibiotics you are prescribed may not work for your family/whnau member, friend or neighbours illness. They might not need antibiotics at all. If they do, they might need a different dose or type of antibiotic. They may have an allergy or another condition or be taking other medicines that mean your antibiotics are not suitable. Using antibiotics when they are not needed, or taking the wrong antibiotic, exposes bacteria to antibiotics unnecessarily, which encourages antibiotic resistance.

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What Can You Do To Combat Antibiotic Resistance

We need to re-assess our relationship with antibiotics otherwise, we risk undermining their effectiveness and ushering in a postbiotic era where resistant infections claim millions of lives.

Governments worldwide continue to allocate large amounts of resources to tackling antibiotic resistance, but we all have a part to play. Here are a few steps you can take to combat antibiotics resistance:

1.) Keep up to date with your vaccinations

2.) Finish your pills

Even if your symptoms disappear, it is vital that you always finish a course of antibiotics as instructed by your doctor. Otherwise, you increase the risk of bacteria gaining resistance.

Have you ever watched a movie where the protagonist spares the villain, only for him to come back more dangerous than ever down the line? Not finishing a course of antibiotics is much the same.

3.) Dont share your prescriptions

Never share your prescriptions with others or take someone else’s medication, as it increases the risk of bacteria gaining resistance.

4.) Dont take antibiotics for viral infections

Ask your doctor whether antibiotics are appropriate for your illness- if its viral, then they cannot help.

Drug Resistance As A Continued Process

Microorganisms are highly astute and evolve mechanisms swiftly to endure and proliferate in environments turning unfavorable. Although antibiotic-resistance started appearing soon after the clinical introduction of antibiotics, the problem was slow and ignored initially as a matter of low distress. Sulfonamide-resistant Streptococcus pyogenes appeared in the human clinical settings in early the 1930s, while penicillin-resistant S. pyogenes was noted in the 1940s. Emergence of multidrug-resistant bacteria was highlighted in the 1950s .

Table 1. Overview of the development of bacterial resistance against common antibiotics.

Two distinct pathways, namely vertical evolution , and horizontal evolution are regarded as prime modes of development of antibiotic-resistance. The comprehensive genomic analysis of human and animal pathogens has shown that horizontal gene transfer is an important mechanism of transfer of antibiotic-resistant genes among microorganisms .

The antibiotic resistance, though a grave concern, was overlooked for a long period . However, incidences that attracted the attention of clinicians and biochemists included detection of bacteria carrying extended spectrum -lactamases imparting resistance to penicillins and cephalosporins, extensively drug-resistant Mycobacterium tuberculosis, and multidrug-resistant Acinetobacter baumannii, Enterobacteriaceae, Neisseria gonorrhoeae, and Pseudomonas aeruginosa .

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