Monday, November 28, 2022

What Antibiotics Treat Lyme Disease In Humans

Stage : Early Localized Disease

Antibiotics for Lyme Disease

Symptoms of Lyme disease usually start 1 to 2 weeks after the tick bite. One of the earliest signs of the disease is a bulls-eye rash.

The rash occurs at the site of the tick bite, usually, but not always, as a central red spot surrounded by a clear spot with an area of redness at the edge. It may be warm to the touch, but it isnt painful and doesnt itch. This rash will gradually fade in most people.

The formal name for this rash is erythema migrans. Erythema migrans is said to be characteristic of Lyme disease. However, many people dont have this symptom.

Some people have a rash thats solid red, while people with dark complexions may have a rash that resembles a bruise.

The rash can occur with or without systemic viral or flu-like symptoms.

Other symptoms commonly seen in this stage of Lyme disease include:

What Treatment Approach Did Well Patients And High Responders Use

We asked patients what their treatment approach was and listed four options a) antibiotics, b) alternative treatments, c) both antibiotics and alternative treatments, and d) no treatment at all. High treatment response was most closely associated with the use of antibiotics compared to patients who were using alternative treatments alone or forgoing treatment altogether. Treatment with antibiotics for Lyme disease was far higher among well patients and high responders compared to non-responders .

As you can see in the chart below, many patients who were taking antibiotics were also taking herbal supplements, which can be antimicrobial . So it is possible that there was a synergistic effect between antibiotics and herbal supplements.

Diagnosis And Management Of Lyme Disease

WILLIAM F. WRIGHT, DO, MPH DAVID J. RIEDEL, MD ROHIT TALWANI, MD and BRUCE L. GILLIAM, MD, University of Maryland, Baltimore, Maryland

Am Fam Physician. 2012 Jun 1 85:1086-1093.

Patient information: See related handout on Lyme disease, written by the authors of this article.

Lyme disease is the most common tick-borne illness in the United States. It is caused by the bacterium Borrelia burgdorferi, and is transmitted primarily by the deer tick . Following its discovery in children and adults in Lyme, Conn., in 1977,1 its incidence has increased steadily in the United States.2

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Erythema migrans rash following a tick bite is the only clinical manifestation sufficient to make the diagnosis of Lyme disease in the absence of laboratory confirmation.

A = consistent, good-quality patient-oriented evidence B = inconsistent or limited-quality patient-oriented evidence C = consensus, disease-oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to .

SORT: KEY RECOMMENDATIONS FOR PRACTICE

Erythema migrans rash following a tick bite is the only clinical manifestation sufficient to make the diagnosis of Lyme disease in the absence of laboratory confirmation.

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What Is The Treatment For Lyme Disease

The first-line standard of care treatment for adults with Lyme disease is doxycycline, a tetracycline antibiotic. Other antibiotics that have activity against borrelia include the penicillin-like antibiotic, amoxicillin, and the second generation cephalosporin, Ceftin. The mainstay of treatment is with oral antibiotics, but intravenous antibiotics are sometimes indicated for more difficult to treat cases of neurologic-Lyme disease, such as meningitis, and cases of late Lyme arthritis.

Questions To Ask Your Doctor

Weekly Dose: doxycycline treats a host of human plagues ...
  • I found a tick embedded in my skin, but I cant get it out. What should I do?
  • Ive been bitten by a tick. Do I need to be seen?
  • Do I need a blood test to confirm Lyme disease?
  • Which antibiotic is best for me?
  • How long will I have to take the antibiotic?
  • What tick or insect repellent should I use for me or my child?
  • How long will the symptoms last?
  • What should I do if I still dont feel well a long time after I was bitten?

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Late Or Chronic Lyme Disease Treatment

Experts agree that the earlier you are treated the better, since early treatment is often successful. Unfortunately, a substantial portion of patients treated with short-term antibiotics continue to have significant symptoms. The quality of life of patients with chronic Lyme disease is similar to that of patients with congestive heart failure. Doctors dont agree about the cause of these ongoing symptoms. The primary cause of this debate is flawed diagnostic testing. There is currently no test that can determine whether a patient has active infection or whether the infection has been eradicated by treatment.

The IDSA thinks Lyme disease symptoms after treatment represent a possibly autoimmune, post-Lyme syndrome that is not responsive to antibiotics. The IDSA essentially regards Lyme disease as an acute infection like strep throat that can be treated with a short course of antibiotics. The IDSA guidelines are now eight years old and do not reflect recent science.

ILADS physicians believe that ongoing symptoms probably reflect active infection, which should be treated until the symptoms have resolved. These physicians use treatment approaches employed for persistent infections like tuberculosis, including a combination of drugs and longer treatment durations. The ILADS guidelines have just recently been updated using a rigorous review of the medical literature.

Which Antibiotics Are Used For Lyme Disease Treatment

In the treatment of Lyme disease, the following categories of antibiotics are used:

  • Penicillin has a bactericidal effect, such as amoxycycline and penicillin V. They are administered orally. The concentration of this type of antibiotic in the blood should be constantly monitored as it tends to fluctuate significantly.
  • Tetracycline the antibiotic group includes, among others doxycycline and minocycline. If these antibiotics are given to the patient in too low doses, they will only act bacteriostatic. Low blood levels of the drug cause failure in the treatment of Lyme disease at every stage. At the same time, high doses of this type of antibiotics are generally poorly tolerated by the patients body. Doxycycline can be administered orally or intravenously.
  • Cephalosporins it is a new generation of antibiotics developed in the third phase of research. Cephalosporins in their latest version are very effective in the fight against Lyme disease and more. The danger is that this type of antibiotic causes some side effects in the digestive system. It is also quite expensive.

Antibiotics are administered intravenously or orally. The patients doctor decides about the application of a particular therapeutic therapy.

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Why Are Antibiotics The First Line Of Treatment For Lyme Disease

The use of antibiotics is critical for treating Lyme disease. Without antibiotic treatment, the Lyme disease causing bacteria can evade the host immune system, disseminate through the blood stream, and persist in the body. Antibiotics go into the bacteria preferentially and either stop the multiplication of the bacteria or disrupt the cell wall of the bacteria and kill the bacteria . By stopping the growth or killing the bacteria the human host immune response is given a leg up to eradicate the residual infection. Without antibiotics, the infection in Lyme disease can evade the host immune system and more readily persist.

Azlocillin Comes Out On Top

How to Use Antibiotics for Lyme Disease Treatment

The drug, which is not on the market, was tested in mouse models of Lyme disease at seven-day, 14-day and 21-day intervals and found to eliminate the infection. For the first time, azlocillin was also shown to be effective in killing drug-tolerant forms of B. burgdorferi in lab dishes, indicating that it may work as a therapy for lingering symptoms of Lyme disease.

Pothineni and Rajadas have patented the compound for the treatment of Lyme disease and are working with a company to develop an oral form of the drug. Researchers plan to conduct a clinical trial.

Rajadas is also a professor of bioengineering and therapeutic sciences at the University of California-San Francisco.

Other Stanford co-authors are Hari-Hara S. K. Potula, PhD, senior research scientist postdoctoral scholars Aditya Ambati, PhD, and Venkata Mallajosyula, PhD senior research scientist Mohammed Inayathullah, PhD and intern Mohamed Sohail Ahmed.

A researcher at Loyola College in India also contributed to the work.

The study was funded by the Bay Area Lyme Foundation and Laurel STEM Fund.

  • Tracie White

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Treatment For Erythema Migrans

People treated with appropriate antibiotics in the early stages of Lyme disease usually recover rapidly and completely. Early diagnosis and proper antibiotic treatment of Lyme disease can help prevent late Lyme disease.

Treatment regimens listed in the following table are for the erythema migrans rash, the most common manifestation of early Lyme disease. These regimens may need to be adjusted depending on a persons age, medical history, underlying health conditions, pregnancy status, or allergies. Consult an infectious disease specialist regarding individual patient treatment decisions.

Treatment regimens for localized Lyme disease.

Age Category
100 mg, twice per day orally N/A
500 mg, three times per day orally N/A
500 mg, twice per day orally N/A
4.4 mg/kg per day orally, divided into 2 doses 100 mg per dose
50 mg/kg per day orally, divided into 3 doses 500 mg per dose
30 mg/kg per day orally, divided into 2 doses 500 mg per dose

*When different durations of antibiotics are shown to be effective for the treatment of Lyme disease, the shorter duration is preferred to minimize unnecessary antibiotics that might result in adverse effects, including infectious diarrhea and antimicrobial resistance.

NOTE: For people intolerant of amoxicillin, doxycycline, and cefuroxime, the macrolide azithromycin may be used, although it is less effective. People treated with azithromycin should be closely monitored to ensure that symptoms resolve.

Stage : Late Disseminated Lyme Disease

Late disseminated Lyme disease occurs when the infection hasnt been treated in stages 1 and 2. Stage 3 can occur months or years after the tick bite.

This stage is characterized by:

  • arthritis of one or more large joints
  • brain disorders, such as encephalopathy, which can cause short-term memory loss, difficulty concentrating, mental fogginess, problems with following conversations and sleep disturbance
  • numbness in the arms, legs, hands, or feet

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Possible Alternative Treatment For Lyme Disease

Date:
University of Oklahoma
Summary:
Researchers have described a new antibiotic that appears to have the potential to cure Lyme disease.

As if COVID and RSV weren’t bad enough, incidents of Lyme disease — a potentially serious disease caused by the bacteria Borrelia burgdorferi and transmitted following a bite of an infected deer tick — also are on the rise in the United States.

Lyme disease affects an estimated 300,000 people in the United States alone. Humans and animals can be infected with B. burgdorferi following the bite of an infected deer tick, also known as the black-legged tick. About 80% of those who contract the disease will develop a bulls-eye rash around or near the site of the bite anywhere from three to 30 days following the bite.

Although early antibiotic treatment is effective for most patients, some 10-20% of patients continue to suffer from symptoms that may include fatigue, muscle pain and cognitive impairment for over six months after therapy. The significance of this debilitating disease has been recently brought into focus by a set of very similar symptoms in patients with “Long COVID.”

The antibiotics currently used to treat Lyme disease are broad-spectrum with significant effects on the human gut microbiome and the potential for increasing resistance in non-target bacteria, Zgurskaya explained, adding that the team sought to identify a compound acting with a narrower spectrum of activity against B. burgdorferi.

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What Happens At Your Appointment

Doxycycline For Lyme : For early Lyme disease, 10 days of ...

The GP will ask about your symptoms and consider any rash or recent tick bites you know about.

Lyme disease can be difficult to diagnose. It has similar symptoms to other conditions and there’s not always an obvious rash.

2 types of blood test are available to help confirm or rule out Lyme disease. But these tests are not always accurate in the early stages of the disease.

You may need to be retested if you still have Lyme disease symptoms after a negative result.

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Cdc Supports The Development Of New Tests

New tests may be developed as alternatives to one or both steps of the two-step process. Before CDC will recommend new tests, they must be cleared by the Food and Drug Administration . For more details, see: Recommendations for Test Performance and Interpretation from the Second National Conference on Serologic Diagnosis of Lyme Disease.

Prevention Of Tick Bites

The best currently available method for preventing infection with B. burgdorferi and other Ixodes-transmitted infections is to avoid tick-infested areas . If exposure to I. scapularis or I. pacificus ticks is unavoidable, a number of measures may help to decrease the risk that ticks will attach and subsequently transmit infection. The use of protective clothing may interfere with attachment by ticks by increasing the time required for ticks to find exposed skin, thus facilitating their recognition and removal. By wearing light-colored clothing , persons in areas of endemicity may also be more likely to see ticks before they have attached.

Daily inspections of the entire body to locate ticks also provide an opportunity to prevent transmission of tick-borne infections . Attached ticks should be removed promptly with fine-toothed forceps, if possible . Tick and insect repellents applied to the skin and clothing provide additional protection .

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Chronic Lyme Disease Or Postlyme Disease Syndrome

Following an episode of Lyme disease that is treated appropriately, some persons have a variety of subjective complaints . Some of these patients have been classified as having chronic Lyme disease or postLyme disease syndrome, which are poorly defined entities. These patients appear to be a heterogeneous group. Although European patients rarely have been reported to have residual infection with B. burgdorferi , this has yet to be substantiated either in a large series of appropriately treated European patients or in a study of North American patients. Residual subjective symptoms that last weeks or months also may persist after other medical diseases . It has also been recognized that the prevalence of fatigue and/or arthralgias in the general population is > 10% .

In areas of endemicity, coinfection with B. microti or the Ehrlichia species that causes HGE may explain persistent symptoms for a small number of these patients . Randomized controlled studies of treatment of patients who remain unwell after standard courses of antibiotic therapy for Lyme disease are in progress. To date, there are no convincing published data showing that repeated or prolonged courses of oral or iv antimicrobial therapy are effective for such patients. The consensus of the IDSA expert-panel members is that there is insufficient evidence to regard chronic Lyme disease as a separate diagnostic entity.

Little Hope Of Improvement

Lyme Disease Treatment – Johns Hopkins (4 of 5)

There’s currently no plan for getting rid of the ticks for good, and it wouldn’t be an easy task either. The little parasites are quite robust and can survive a cycle in the washing machine as well as time in the freezer. If you have a tick bite, make sure your encephalitis vaccination is up-to-date.

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How Is Lyme Disease Treated

In the early stages, Lyme disease is treatable with antibiotics such as doxycycline. However, such medications can disrupt the gut microbiome, leading to symptoms such as diarrhea. At worst, the antibiotic could promote the development of antibiotic resistance. However, if Lyme disease is not treated, it becomes chronic and keeps coming back.

In the US and Canada, there used to be a vaccination against Lyme disease, called LYMErix. In 1998, it was approved by the US national public health agency CDC for high-risk patients, but in 2002, GlaxoSmithKline discontinued the vaccine, saying it was selling poorly.

What Is The Treatment

Most cases of Lyme disease can be effectively treated with 2 to 4 weeks of antibiotics. Depending on the symptoms and when you were diagnosed, you may require a longer course or repeat treatment with antibiotics.

Some people experience symptoms that continue more than 6 months after treatment. Research continues into the causes of these persistent symptoms and possible treatment methods.

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Essential Oils For Lyme Disease

It is believed that many essential oils have antimicrobial activities, and some people with persistent Lyme disease symptoms have turned to essential oils to help reduce symptoms of the disease.

Researchers tested 34 essential oils against B. burgdorferi in the lab and found cinnamon bark, clove bud, citronella, wintergreen, and oregano show strong activity against the bacterium that causes Lyme disease, even more effectively than daptomycin, the gold standard antibiotic many people with Lyme disease are prescribed.

These results indicate that essential oils show promise as treatments for persistent Lyme disease, but clinical trials are needed in order to show their effectiveness in humans.

When used properly, most essential oils are safe and free of adverse side effects. However, it is important to use them carefully. They can irritate the skin if not properly diluted, and some should not be taken internally.

Purchase high-quality essential oils that go through testing to ensure the product is safe to use. Follow the usage and dilution instructions on the label carefully. Talk with your healthcare professional before using essential oils to avoid drug interactions with any medications you are taking.

For Memory Concentration And Focus

Antibiotic Doxycycline Works No Better Than Placebo In ...

Improving memory is a challenge. In Lyme disease, short-term memory problems and word-retrieval problems are common. These often improve substantially with appropriate antibiotic therapy. Over time, most patients regain their cognitive function.

When memory is a problem, consider that this could due to a primary problem with attention or with mood. An individual who can’t focus won’t be able to remember because he/she didn’t “attend” to the item in the first place. This happens to all of us when we hear someone’s name at a party if we don’t focus on the name and perhaps make a mental association to the name to enhance memory storage, we will forget that name within minutes. Patients with depression often experience problems with memory and verbal fluency when the depression is resolved, the memory and verbal fluency typically resolve as well.

  • Medications: Attention can be improved with certain medications, such as bupropion , atomoxetine , modafinil , or stimulants . Medications that temporarily slow cognitive decline in Alzheimer’s disease or memantine ) have not been studied in Lyme disease.
  • There is some evidence that online brain training programs can enhance concentration or processing speed.
  • Neurofeedback may be helpful in improving attention, as well as in improving sleep and reducing pain. This has been studied for migraines, fibromyalgia, and ADHD.

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