Thursday, April 18, 2024

Factors Contributing To Antibiotic Resistance

Antimicrobial Resistance And The Water Sanitation And Hygiene Problem

Antibiotic Resistance (Antibiotics – Lecture 9)

This section provides an overview of AMR, an introduction to the issue as a global public health problem and summarises how various environmental issues have contributed to the development of the AMR crisis. It briefly discusses the limited focus placed on the role of environmental factors in propagating resistance, and proposes that various environmental determinants could be playing an important role in the development and spread of AMR.

The development of AMR occurs when a drug is no longer able to inhibit or control the action of a microorganism that was previously sensitive to it. As such, the usual treatment regime is no longer effective, resulting in difficulty to control infections, increased risk of spread of infection to others, and in some cases, increased risk of death in some patients when compared with the risk in those infected by non-resistant pathogens . Antibiotics are antimicrobials that are used to treat bacterial infections . AMR develops as part of a natural evolutionary process for microorganisms including bacteria, parasites and viruses .

Complex interactions amongst environmental- and health-related factors that contribute to the spread of antimicrobial resistance. The figure summarises how various often interlinked factors contribute to contamination of the environment with the transfer of antibiotic resistance genes and antibiotic-resistant bacteria going in both directions, perpetuating the cycle of antimicrobial resistance

Global Antibiotic Research And Development Partnership

A joint initiative of WHO and Drugs for Neglected Diseases initiative , GARDP encourages research and development through public-private partnerships. By 2023, the partnership aims to develop and deliver up to four new treatments, through improvement of existing antibiotics and acceleration of the entry of new antibiotic drugs.

How Antibiotic And Antifungal Use Affects Resistance

Antibiotics and antifungals save lives, but their use can contribute to the development of resistant germs. Antimicrobial resistance is accelerated when the presence of antibiotics and antifungals pressure bacteria and fungi to adapt.

Antibiotics and antifungals kill some germs that cause infections, but they also kill helpful germs that protect our body from infection. The antimicrobial-resistant germs survive and multiply. These surviving germs have resistance traits in their DNA that can spread to other germs.

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World Antimicrobial Awareness Week

WAAW was previously called World Antibiotic Awareness Week. Since 2020, it has been called World Antimicrobial Awareness Week. This reflects the broadened scope of WAAW to include all antimicrobials including antibiotics, antifungals, antiparasitics and antivirals. Held annually since 2015, WAAW is a global campaign that aims to raise awareness of antimicrobial resistance worldwide and encourage best practices among the general public, health workers and policy makers to slow the development and spread of drug-resistant infections. The Tripartite Executive Committee decided to set all future WAAW dates as 18 to 24 November. The overarching slogan used for the last 5 years was Antibiotics: Handle with Care. This was changed to Antimicrobials: Handle with Care in 2020.

Comparison With Expert Opinion

What you need to know about antibiotics

A previous exercise had been undertaken previously with nine experts in antimicrobial resistance who practice in disparate fields, from molecular biology through to translational antimicrobial resistance research, clinical infection practice and veterinary medicine. This panel undertook a two-round Delphi process to similarly rank the perceived contribution of each factor as a cause of global antimicrobial resistance and in addition also ranked the contributory scientific evidence for each factor, and the potential population affected . The results from the public poll related to the relative contribution of factors towards AMR were compared and contrasted to these expert results to explore any divergence.

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What Is Antimicrobial Resistance

Antimicrobial Resistance occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death.

As a result of drug resistance, antibiotics and other antimicrobial medicines become ineffective and infections become increasingly difficult or impossible to treat.

Phenotypic And Genotypic Detection Of Resistance In Salmonella

Drug or antibiotic resistance is the decreased sensitivity of microbes to drug or antibiotics that are capable of causing cell death or inhibition of growth . This is determined through antimicrobial sensitivity testing of Salmonella species in order to determine its susceptibility or resistance to the antibiotics . Resistance in Salmonella is encoded by genes that are present on either chromosome or extra-chromosomal DNA or transferable genetic materials , which is determined by genetic or molecular method . The most common method is the Kirby-Bauer method . Although resistance may occur due to mutation in key genetic loci in the bacterial genome, but most resistance to antimicrobial agents mediated by genes are acquired via mobile genetic elements such as plasmid and transposons . The identification of resistance genotype is accomplished through detection of novel genetic materials and characterization of mutations in specific genes through polymerase chain reaction . Several genetic methods including DNA probes, PCR and other amplification techniques are now used in varieties of clinical laboratories for identification and quantification of pathogenic organisms .

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Protect Yourself And Your Family

  • When preparing food, follow the four steps to food safety:
  • Clean.Wash your hands before and after touching uncooked eggs or raw meat, poultry , seafood, or their juices. Wash your work surfaces, cutting boards, utensils, and dishes before, during, and after cooking.
  • Germs from raw meat, poultry, seafood, and eggs can spread to fruits, vegetables, and other ready-to-eat foods unless you keep them separate. Use one cutting board to prepare raw meats and another for foods that will not be cooked before theyre eaten. Dont put cooked meat on a plate that had raw meat on it.
  • Cook. Use a food thermometer to ensure that foods are cooked to a safe internal temperature: 145°F for whole cuts of beef, pork, lamb, and veal 160°F for ground red meats and egg dishes and 165°F for poultry, including ground chicken and turkey. Get safe cooking temperaturesexternal icon for other foods.
  • Chill. Keep your refrigerator at 40°F or below and refrigerate foods within 2 hours of cooking. Refrigerate within 1 hour if food is exposed to temperatures above 90°F .
  • When around pets and other animals:
  • Wash your hands after touching them, their food, water, poop, belongings , or habitats .
  • Review CDCs Travelers Health recommendations when preparing for international travel.
  • To help slow the spread of antibiotic resistance, take antibiotics only when needed, and take them exactly as prescribed by your healthcare provider.

    Spread Of Resistant Bacteria

    Antibiotic Resistance | Health | Biology | FuseSchool

    Resistant bacteria spread via many routes. Different factors influence spread depending on the setting. Poor hygiene, poor sanitation, and poor infection control are three interconnected key factors contributing to the spread of resistant bacteria in health care facilities, in farms and in the community.

    Bacteria know no boundaries and international traveling and trade help disseminate resistant bacteria across the world. Animals for food production are transported across borders and groceries are exported from most parts of the world, and the bacteria follow along. This contributes to the complexity of the antibiotic resistance problem and underpins the fact that it is a global issue. It does not matter where a resistant bacterium forms. If it is successful and increases in numbers it may quickly spread to other parts of the world in our globalized society.

    Here follows an overview including an introductory video of some of the ways resistant bacteria can spread. For more information, see the selected resources at the bottom of the page, or read more in How did we end up here?

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    Amr Increases When We Use Antibiotics

    The main cause of antibiotic resistance is antibiotic use. When we use antibiotics, some bacteria die but resistant bacteria can survive and even multiply. The overuse of antibiotics makes resistant bacteria more common.

    The more we use antibiotics, the more chances bacteria have to become resistant to them. This means that antibiotics wont work when we need them in the future. If we decrease antibiotic use, the antibiotics may again become effective at killing bacteria.

    Role Of The Funding Source

    The research was funded by the National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance at Imperial College London in partnership with Public Health England . However, the study funders had no influence on how the data were collected, analysed, interpreted or presented. The views expressed are those of the author and not necessarily those of the NHS, the NIHR, the Department of Health or Public Health England.

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    How Can I Protect Myself And My Family From Antibiotic Resistance

    No one can completely avoid getting an infection, but there are additional steps you can take to protect yourself and your family.

    Protect yourself and your family from antibiotic resistance by

    • doing your best to stay healthy and keep others healthy,
    • cleaning hands,
    • staying home when sick, and
    • getting recommended vaccines, such as the flu vaccine.

    Taking antibiotics only when they are needed is an important way you can protect yourself and your family from antibiotic resistance. Talk to your doctor about the best treatment if you are sick. Never pressure your doctor to prescribe an antibiotic.

    When antibiotics arent needed, they wont help you, and their side effects could still cause harm. Ask your doctor or pharmacist about steps you can take to feel better when an antibiotic isnt needed.

    If your doctor decides an antibiotic is the best treatment when you are sick:

    • Take the antibiotic exactly as your doctor tells you.
    • Do not share your antibiotic with others.
    • Do not save them for later. Talk to your pharmacist about safely discarding leftover medicines.
    • Do not take antibiotics prescribed for someone else. This may delay the best treatment for you, make you even sicker, or cause side effects.
    • Talk with your doctor and pharmacist if you have any questions about your antibiotics.

    Need For Coordinated Action

    What you need to know about antibiotics

    AMR is a complex problem that requires a united multisectoral approach. The One Health approach brings together multiple sectors and stakeholders engaged in human, terrestrial and aquatic animal and plant health, food and feed production and the environment to communicate and work together in the design and implementation of programmes, policies, legislation and research to attain better public health outcomes.

    Greater innovation and investment is required in operational research, and in research and development of new antimicrobial medicines, vaccines, and diagnostic tools especially those targeting the critical gram-negative bacteria such as carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii. The launch of the Antimicrobial Resistance Multi Partner Trust Fund , the Global Antibiotic Research & Development Partnership , AMR Action Fund and other funds and initiatives could fill a major funding gap. Various governments are piloting reimbursement models including Sweden, Germany, the USA and the United Kingdom. More initiatives are needed to find lasting solutions.

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    Antibiotic Resistance Food And Food Animals

    The American food supply is among the safest in the world, but people can still get food poisoning by eating contaminated foods. Some food poisoning is caused by antibiotic-resistant bacteria. Symptoms of infection with antibiotic-resistant bacteria are like other food poisoning symptoms, which can be mild to life-threatening and include diarrhea, nausea, and vomiting.

    Antibiotics are medicines that kill or stop the growth of bacteria. Antibiotic resistance happens when bacteria develop the ability to survive or grow despite being exposed to antibiotics designed to kill them.

    Antibiotics save lives, but any time antibiotics are used, they can contribute to the development and spread of antibiotic resistance. Antibiotic resistance spreads to bacteria through people, animals, and the environment. Improving antibiotic use, including reducing unnecessary use, can help stop resistance from spreading.

    Learn what CDC is doing to help stop antibiotic-resistant infections from food and animals, and how you can protect yourself and your family.

    Drug Resistance In Mycobacterium Tuberculosis

    Antibiotic resistant Mycobacterium tuberculosis strains are threatening progress in containing the global tuberculosis epidemic. WHO estimates that, in 2018, there were about half a million new cases of rifampicin-resistant TB identified globally, of which the vast majority have multi-drug resistant TB , a form of tuberculosis that is resistant to the two most powerful anti-TB drugs. Only one-third of the approximately half a million people who developed MDR/RR-TB in 2018 were detected and reported. MDR-TB requires treatment courses that are longer, less effective and far more expensive than those for non-resistant TB. Less than 60% of those treated for MDR/RR-TB are successfully cured.

    In 2018, an estimated 3.4% of new TB cases and 18% of previously treated cases had MDR-TB/ RR-TB and the emergence of resistance to new last resort TB drugs to treat drug resistant TB poses a major threat.

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    Developing And Developed Nations

    Lack of research on new antibiotics

    Despite the evidence that antibiotic resistance is a key issue and an emerging global threat, research on new antibiotic medications to combat infectious diseases is slowing down. While the period between the 1950s and 1970s led to discoveries of many new antibiotics from a variety of different classes, no new antibiotic class has been discovered since then. Only 3% of the new medications approved by the FDA between January 1998 to December 2002 were new antibacterials. While there were 19 antibacterial new drug application approvals between 1980 and 1984, there were only six such approvals from 2010 to 2014. 15 of the 18 pharmaceutical companies have left the antibiotic field and the mergers between different companies have diminished the number and diversity of research teams. While the discovery of antibiotics in the early 20th century heralded in the golden age of antibiotic research, currently there are little incentives to continue on the same path. The WHO published a report in September 2017 arguing that the antibiotics currently in clinical development are not sufficient to counter rising antimicrobial resistance, particularly the pathogens with greatest threat to human.

    Estimation Steps One And Two: Deaths In Which Infection Played A Role By Infectious Syndrome

    Antibiotics and Resistance





    Crit Care Med.N Engl J Med.JAMA.


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    Antibiotic Resistance And Factors For It

  • To Discuss Various Factors Affecting AntibioticResistance
  • Antibiotic & Antibiotic Resistance

    Antibiotic: any of various chemical substances,produced by various microorganisms, esp. fungi, or made synthetically and capable of destroying or inhibiting the growth of microorganism.

    People may exhibit allergic reactions to antibiotics, but they are not resistant to them. It is the bacteria themselves, not the infected host, which become resistant.

    Antibiotic Resistance

    Antibiotic Resistance: the ability of bacteria and other microorganisms to withstand an antibiotic to which they

    were once sensitive

    Tolerance of micro-organisms to inhibitory action of antibiotics.

    Resistance to antibiotics is a biological phenomenon that can be accelerated by a variety of factors, including human practices.

    Resistance Can be: Drug Tolerance, Drug Destruction, Drug Impermeability, Cross resistance.

    Antibiotic Resistance Is A Serious Worldwide Problem

    The monetary cost of treating antibiotic resistant infections worldwide is estimated to be many billions of dollars per year.

    According to the researchers : the resistance to antibiotics is increasing at a faster pace than it can be controlled.

    Since antibiotic resistance can pass from bacterium to bacterium and resistant bacterial infections can pass from

    person to person. Thus, antibiotic use and antibiotic resistance can eventually affect an entire community.

    Factors Affecting Antibiotic Resistance

    Forget to take medication

    What Factors Contribute To Antibiotic Resistance


    Antibiotics are essential medicines, Many medicines are effective in treating bacterial infections Antibiotics can help to stop the disease from spreading. Antibiotics can also help to prevent major illness consequences,

    However, several antibiotics that were once treatment options for bacterial infections are no longer effective. Furthermore, certain antibiotics are ineffective against some microorganisms Antibiotic resistance occurs when an antibiotic no longer works against a particular strain of bacteria. One of the worlds most pressing health issues is antibiotic resistance.

    Antibiotic abuse and misuse are major contributors to resistance to antibiotics. The general public, health care providers, and hospitals can all play a role in ensuring that the medications are used correctly. Antibiotic resistance may be slowed as a result of this, At Albro pharma, we have quality medicine about antibiotics that are recognized nationwide.

    What factors contribute to antibiotic resistance?

    When bacteria mutate in any way, they become resistant to drugs. The modification could either protect the bacteria from the drugs effects or limit the drugs ability to reach the bacterium. Alternatively, the alteration could cause the bacteria to alter or destroy the medicine.

    It is natural and anticipated for microorganisms to develop antibiotic resistance. However, how medications are reused has an impact on how quickly and to what extent resistance develops.

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    How Is The Crisis Currently Being Handled

    The existence of the antimicrobial crisis and its importance to the future of the human race is widely acknowledged among peak health care bodies such as the CDC and the WHO . Along with acknowledgment of the problem, these bodies provide a number of recommendations that have contributed to actions intended to manage the crisis. These recommendations have resulted in a series of actions and programs designed to address the AMR crisis. These activities fall into two main categories: those that address the prevention of disease so that the need for antimicrobials will be limited and those that provide new or more efficient treatments to either augment or supplant existing antimicrobial therapies. In brief, these measures include disease prevention through the use of vector control, vaccination, public education, clinical education, and legislative action is recommended. Rapid and effective disease management through the use of diagnostics for microbial identification, microbial sensitivity testing to existing antimicrobials to determine appropriate therapies are also advocated .

    All of these initiatives have been useful in improving the health of their target populations. However, the accelerating incidence of infections resistant to antimicrobial therapy indicates that these measures should be expanded and additional measures implemented if resistant microbial infection is to be contained.

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